Cavin Ward-Caviness, PhD

August 30, 2018

Cavin Ward-Caviness, PhD

Computational Biologist/Principal Investigator of US EPA

Core Faculty
Phone: (919) 966-5445 | Office: 104 Mason Farm Road
Email: ward-caviness.cavin@epa.gov | Website: https://www.wc-lab.com/

Research Areas: Computational Genomics, Statistical and Population Genetics
Research Interests: My primary research interest is in using large clinical databases to uncover environmental and social health risks. In addition I am interested in furthering the use of machine learning in environmental epidemiology and uncovering molecular biomarkers for environmental health risk and the molecular mechanisms by which environmental exposures are translated into health outcomes.


Shehzad Sheikh, MD, PhD

August 30, 2018

Shehzad Sheikh, MD, PhD

Associate Professor of Genetics and Medicine

Resource Faculty
Phone: (919) 966-0745 | Office: 7320 Medical Biomolecular Research Building
Email: sheisx@med.unc.edu | Website: http://sheikhlab.web.unc.edu/

Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology
Research Interests: We seek to understand how information is encoded and dynamically utilized in immune cells from healthy and disease prone intestines (Crohn’s disease and Ulcerative colitis). We focus specifically on genes that regulate response to the bacteria that normally reside in our intestines. We use genome-sequencing technology to precisely identify regions throughout the genome that are potential ‘on’ or ‘off’ switches for these genes.


Ian Davis, MD, PhD

August 29, 2018

Ian Davis, MD, PhD

G. Denman Hammond Professor of Genetics and Pediatrics

Resource Faculty
Phone: (919) 966-5360 | Office: 21-219 Lineberger Comprehensive Cancer Center
Email: ian_davis@med.unc.edu | Website: http://davislab.web.unc.edu/

Research Areas: Computational Genomics, Bioinformatics
Research Interests: Epigenomic and transcriptomic consequences of genetic alterations in cancer and applications to therapeutic discovery.


Katherine A. Hoadley, PhD

August 21, 2018

Katherine Hoadley, PhD

Assistant Professor of Genetics

Resource Faculty
Phone: (919) 962-8416 | Office: 5212 Marsico Hall
Email: hoadley@med.unc.edu | Website: https://unclineberger.org/people/profiles/katherine-hoadley

Research Areas: Computational Genomics, Bioinformatics, Computational Systems Biology
Research Interests: My research interest is in genomic characterization and integrative genomic approaches to better understand cancer. My group is part of the NCI Genome Data Analysis Center focused on RNA expression analysis. We have a number of ongoing projects including developing molecular classifications for potential clinical utility, developing methods for deconvolution to understand bulk tissue heterogeneity, analysis of driver negative cancers, and analysis of ancestry markers with cancer features.


Hyejung Won

August 13, 2018

Hyejung Won, PhD

Assistant Professor of Department of Genetics

Core Faculty
Phone: (919) 966-4069 | Office: 7202B Mary Ellen Jones Building, 116 Manning Dr.
Email: hyejung_won@med.unc.edu | Website: http://www.wonlab.org/

Research Areas: Bioinformatics, Statistical and Population Genetics
Research Interests: We try to bridge the gap between genetic risk factors for psychiatric illnesses and neurobiological mechanisms by decoding the regulatory relationships in human brain. In particular, we implement Hi-C, a genome-wide chromosome conformation capture technique, to identify the folding principle of the genome in human brain. We then leverage this information to identify the functional impacts of the common variants associated with neuropsychiatric disorders.


Hector Franco

June 5, 2018

Hector L Franco, PhD

Assistant Professor of Genetics; UNC Lineberger Cancer Center

Resource Faculty
Phone: (919) 966-5269 | Office: 5109 Marsico Hall
Email: hfranco@med.unc.edu | Website: https://www.thefrancolab.org/

Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology
Research Interests: The Franco lab has a long-standing interest in gene regulation, epigenetics, chromatin and RNA biology, especially as it pertains to cancer. We address these research aims by using an interdisciplinary approach that combines molecular and cellular techniques with functional genomic and computational approaches.


Doug Phanstiel, PhD

February 9, 2018

Doug Phanstiel, PhD

Assistant Professor of Cell Biology & Physiology

Resource Faculty
Phone: 919-843-8847 | Office: 4019 Thurston Bowles Building
Email: douglas_phanstiel@med.unc.edu | Website: http://www.unc.edu/~dphansti/

Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology
Research Interests: We employ experimental and computational approaches to study the mechanisms through which enhancers and three-dimensional chromatin structure regulate gene transcription during cellular differentiation. The goals of our computational work include improved detection and quantification of three-dimensional chromatin structures and new tools for visualizing multi-dimensional genomic data.


Jill Dowen

November 28, 2017

Jill Dowen, PhD

Assistant Professor of Biochemistry & Biophysics and Biology

Resource Faculty
Phone: 919-962-8132 | Office: 3360 Genome Sciences Building
Email: jilldowen@unc.edu | Website: http://jilldowenlab.web.unc.edu/

Research Areas: Bioinformatics, Computational Genomics, Chromosome Conformation
Research Interests: Our research program integrates the areas of transcriptional regulation, three-dimensional genome organization and functional genomics to understand how the architecture of the genome influences gene expression during development and disease.


Mike Love

July 27, 2017

Mike Love, PhD

Assistant Professor of Biostatistics & Genetics

Faculty
Phone: (919) 966-7266 | Office: 4115E McGavran-Greenberg Hall
Email: milove@email.unc.edu | Website:

Research Areas:
Research Interests: Dr. Love’s research concerns statistical and computational methods for the analysis of high-throughput sequencing assays to facilitate biomedical and biological research. He has developed a number of open source software packages for the analysis of RNA sequencing (RNA-seq) data, including the DESeq2 package for differential gene expression analysis.