Curriculum in Bioinformatics & Computational Biology - UNC Chapel Hill

Welcome!

UNC Old Well Bioinformatics and computational biology are related fields that focus on the development or application of quantitative tools to address modern biological problems. The Curriculum in Bioinformatics & Computational Biology, started in 2002,  trains students to become sophisticated, interdisciplinary researchers using state-of-the-art computational methods to advance biological discovery.  The BCB Curriculum currently supports a standalone PhD granting program, and also a certificate of specialization for students working toward their PhDs in other affiliated departments at UNC-Chapel Hill.

The BCB Curriculum is supported and administered by the Carolina Center for Genome Sciences.  The Curriculum also receives financial support from the College of Arts & Sciences, the School of Medicine, and the National Institutes of Health. 

 


This Week's Seminars:

Weekly Colloquium - Mondays @ 4:40 pm in 2025 Bondurant Hall
March 30 - Martin Buchkovich BCB Student Presentation, "Quantitative sequence data identifies allelic differences in protein binding at genome-wide association loci" flyer

Research In Progress Seminar - Tuesdays @ 4pm in 2004 Marsico Hall
March 31 - Jeanette Baran-Gale / Sethupathy & Purvis Labs "Alternative polyadenylation in breast cancer" flyer

 


In The News:

Meredith Corley (graduate student, Laederach Lab) is first author on a paper published last week in Nucleic Acids Research that was titled: “Detecting riboSNitches with RNA folding algorithms: a genome-wide benchmark”. In the paper, Meredith and collaborators evaluate 11 different RNA folding algorithms’ riboSNitch prediction performance from a recently published human genome-wide parallel analysis of RNA structure (PARS) study. This study establishes best practices for predicting how SNVs (Single Nucleotide Variants) will affect transcriptome structure and builds on a growing body of evidence suggesting RNA structure is a key component of cellular regulation. See student pubs page for complete citation.



Sara Selitsky (graduate student, Sethupathy & Lemon Labs) has recently first-authored a paper published in Scientific Reports (Nature's open access journal), titled Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C. In this study, Selitsky et al. identify for the first time in human tissue the presence of a class of small RNAs derived from tRNAs.  They find that tRNA-derived RNAs are even more abundant than microRNAs in the liver of patients chronically infected with hepatitis B or C, and that they are dysregulated in hepatocellular carcinoma. These findings open a new field of study that may suggest new approaches for diagnosis and treatment of chronic liver diseases. Jeanette Baran-Gale, also a BCB student (Sethupathy & Purvis Labs), is a contributing author on the paper. See student pubs page for complete citation.

 

 

Tim Elston, PhD

Tim Elston, PhD
Curriculum Director
4092 Genetic Medicine Bldg.
CB# 7365
Chapel Hill NC 27599
919-843-7670

Will Valdar, PhD

Will Valdar, PhD
Curriculum Deputy Director
Student Progression Director
5113 Genetic Medicine Bldg.
CB# 7264
Chapel Hill, NC 27599
919-843-2833

John Cornett

John Cornett
Curriculum Administrator
5009 Genetic Medicine Bldg. 
CB# 7264
Chapel Hill NC 27599
919-962-4728

 


UNC campus photo by Betsy Clarke