Bioinformatics and computational biology are related fields that focus on the development or application of quantitative tools to address modern biological problems. The Curriculum in Bioinformatics & Computational Biology, started in 2002, trains students to become sophisticated, interdisciplinary researchers using state-of-the-art computational methods to advance biological discovery. The BCB Curriculum currently supports a standalone PhD granting program, and also a certificate of specialization for students working toward their PhDs in other affiliated departments at UNC-Chapel Hill.
The BCB Curriculum is supported and administered by the Carolina Center for Genome Sciences. The Curriculum also receives financial support from the College of Arts & Sciences, the School of Medicine, and the National Institutes of Health.
This Week's Seminars:
Weekly Colloquium - Mondays @ 4:40 pm in 2025 Bondurant Hall
March 30 - Martin Buchkovich BCB Student Presentation, "Quantitative sequence data identifies allelic differences in protein binding at genome-wide association loci" flyer
Research In Progress Seminar - Tuesdays @ 4pm in 2004 Marsico Hall
March 31 - Jeanette Baran-Gale / Sethupathy & Purvis Labs "Alternative polyadenylation in breast cancer" flyer
In The News:
Meredith Corley (graduate student, Laederach Lab) is first author on a paper published last week in Nucleic Acids Research that was titled: “Detecting riboSNitches with RNA folding algorithms: a genome-wide benchmark”. In the paper, Meredith and collaborators evaluate 11 different RNA folding algorithms’ riboSNitch prediction performance from a recently published human genome-wide parallel analysis of RNA structure (PARS) study. This study establishes best practices for predicting how SNVs (Single Nucleotide Variants) will affect transcriptome structure and builds on a growing body of evidence suggesting RNA structure is a key component of cellular regulation. See student pubs page for complete citation.
Sara Selitsky (graduate student, Sethupathy & Lemon Labs) has recently first-authored a paper published in Scientific Reports (Nature's open access journal), titled Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C. In this study, Selitsky et al. identify for the first time in human tissue the presence of a class of small RNAs derived from tRNAs. They find that tRNA-derived RNAs are even more abundant than microRNAs in the liver of patients chronically infected with hepatitis B or C, and that they are dysregulated in hepatocellular carcinoma. These findings open a new field of study that may suggest new approaches for diagnosis and treatment of chronic liver diseases. Jeanette Baran-Gale, also a BCB student (Sethupathy & Purvis Labs), is a contributing author on the paper. See student pubs page for complete citation.
Tim Elston, PhD
Will Valdar, PhD