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Research Area: Bioinformatics

Xihao Li, PhD

February 23, 2024

Xihao Li, PhD

Assistant Professor of Biostatistics & Genetics

Core Faculty
Phone: (919) 843-3656* | Office: 4115D McGavran-Greenberg Hall*
Email: xihaoli@unc.edu | Website: https://xihaoli.org

Research Areas: Bioinformatics; Statistical and Population Genetics
Research Interests: My research interests lie in developing novel statistical methods and computational tools that (1) enable scalable and integrative analysis of large-scale whole-genome/whole-exome sequencing (WGS/WES) data and multi-omics data, (2) empower meta-analysis of large-scale sequencing data of ancestrally-diverse consortiums and biobanks, and (3) prioritize putative causal genetic variants using functional annotation data to better understand the relationships among genomic variation, genome function, and phenotypes.

Yinglong Miao

August 16, 2023

Yinglong Miao, PhD

Associate Professor of Pharmacology and Computational Medicine

Core Faculty
Phone: 919-962-5696 | Office: 11004C Mary Ellen Jones Building
Email: yinglong_miao@med.unc.edu | Website: http://miaolab.org/

Research Areas: Bioinformatics, Computational Biophysics, Image Analysis
Research Interests: Dr. Miao develops novel theoretical and computational methods and Deep Learning techniques, which speed up molecular simulations by orders of magnitude, and applies these methods for unprecedented simulations of biomolecular dynamics and cellular signaling events. In collaboration with leading experimentalists, the Miao Lab combines complementary simulations and experiments to uncover functional mechanisms and design drugs of important biomolecules, including G-protein-coupled receptors (GPCRs), membrane-embedded proteases, RNA-binding proteins and RNA.

Tessa Andermann, MD MPH

December 12, 2022

Tessa Andermann, MD MPH

Assistant Professor of Medicine

Resource Faculty
Phone: 919-843-0834 | Office: 2341E Medical Biomolecular Research Building
Email: tessa_andermann@med.unc.edu | Website: https://www.med.unc.edu/medicine/infdis/directory/tessa-andermann/

Research Areas: Bioinformatics, Computational Genomics
Research Interests: As an Assistant Professor of Medicine in the Division of Infectious Diseases at UNC-Chapel Hill, Tessa Andermann, MD, MPH, conducts multi-disciplinary research focused on investigating the impact of the intestinal microbiome on cancer outcomes. Her current projects include: 1) Investigating the role of the gut antimicrobial “resistome” in the development of bloodstream and other infections with multi-drug-resistant organisms in patients with hematologic malignancies, 2) developing microbial predictors of therapeutic efficacy and therapy-related gastrointestinal complications following administration of cellular and other immunotherapies in patients with cancer, and 3) using the intestinal microbiome as a tool to inform antimicrobial stewardship in immunocompromised patients.

Brian Miller, MD PhD

February 25, 2022

Brian Miller, MD PhD

Assistant Professor of Medicine, Division of Oncology

Resource Faculty
Phone: 919-966-7763 | Office: 5202 Marsico Hall
Email: BrianMiller@med.unc.edu | Website: http://www.themillerlab.org/

Research Areas: Bioinformatics, Computational Systems Biology, Computational Genomics
Research Interests: The Miller lab is working to improve the efficacy of immunotherapy to treat cancer. Using single-cell transcriptomic and epigenetic techniques, along with functional genomic approaches, we want to understand the determinants of immune cell differentiation and function in the tumor microenvironment.

Shawn Ahmed, PhD

November 12, 2021

Shawn Ahmed, PhD

Professor of Genetics and Biology

Resource Faculty
Phone: 919-843-4780 | Office: 216 Fordham Hall
Email: shawn@med.unc.edu | Website: http://labs.bio.unc.edu/ahmed/

Research Areas: Bioinformatics, Comparative Genomics and Molecular Evolution, Computational Genomics
Research Interests: We are interested in understanding potential functions of nuclear foci that are composed of telomere binding proteins, whose levels can be altered for several generations by a single gamete. This novel form of epigenetic inheritance may be relevant to roles that telomeres play in human aging, in cancer biology, and potentially to the mysterious relationship of environmental stress with human telomere length. We primarily study the nematode C. elegans but are also in translating our work to human biology. We are broadly interested in creative approaches to study telomere biology, genome silencing, small RNAs and transgenerational epigenetic inheritance.

Jeremy Wang, PhD

November 1, 2021

Jeremy Wang, PhD

Assistant Professor of Genetics

Core Faculty
Phone: (919) 886-4006 | Office: 3144 Genome Sciences Building
Email: jeremy_wang@med.unc.edu | Website: http://jwanglab.org/

Research Areas: Bioinformatics, Computational Genomics
Research Interests: Genomic epidemiology of bacterial and viral pathogens, from E. coli to SARS-CoV-2; Metagenomics of the mucosa-associated gut microbiome; Machine-learning classification of pediatric cancers using nanopore sequencing of full-length transcriptomes.

Natalie Stanley, PhD

January 26, 2021

Natalie Stanley, PhD

Assistant Professor of Computer Science

Core Faculty
Phone: 919-590-6018 | Office: Sitterson Hall and Mary Ellen Jones Building
Email: natalies@cs.unc.edu | Website: https://stanleyn.github.io/

Research Areas: Bioinformatics, Computational Systems Biology
Research Interests: Our research is focused on computational and systems immunology, with a particular emphasis on developing new algorithms for extracting information from flow and mass cytometry data. We are also interested in multimodal integration of biological and biomedical data.

Jeremy M. Simon, PhD

July 27, 2020

Jeremy M. Simon, PhD

Research Associate Professor of Genetics; UNC Neuroscience Center

Resource Faculty
Phone: 919-966-4050 | Office: 7018A Mary Ellen Jones Building
Email: jeremy_simon@med.unc.edu | Website: https://www.med.unc.edu/neuroscience/core-facilities/bioinformatics/

Research Areas: Bioinformatics, Computational Genomics
Research Interests: My research is focused on gene expression and gene regulation in primarily mouse and human models of autism, cancer, and environmental exposures, and across development. Through the UNC Neuroscience Center Bioinformatics Core, we collaborate to provide bioinformatics support for high-throughput sequencing-based experiments such as RNA-seq, ChIP-seq, ATAC-seq, and other genomic approaches to labs within the Neuroscience Center, Lineberger Comprehensive Cancer Center, and the School of Medicine.

Alexander Rubinsteyn, PhD

July 23, 2020

Alexander Rubinsteyn, PhD

Assistant Professor of Genetics

Core Faculty
Phone: TBA | Office: 11202B Mary Ellen Jones Building
Email: alex.rubinsteyn@unc.edu | Website: https://rubinsteyn.web.unc.edu/

Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology
Research Interests: Machine learning for adaptive immunity, immunogenomics, and rapid vaccine design targeting cancer neoantigens and emerging pathogens.

Christoph Rau

March 11, 2020

Christoph Rau, PhD

Assistant Professor of Computational Medicine

Core Faculty
Phone: 919-962-5641 | Office: 11004B Mary Ellen Jones Building
Email: ChristophRau@unc.edu | Website: https://raulab.web.unc.edu/

Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology, Statistical and Population Genetics
Research Interests: The Rau lab utilizes populations of mice to study the transcriptomic and epigenomic landscape underlying cardiovascular disorders using a combination of wet and dry-lab techniques.