J. Mauro Calabrese, PhD

Assistant Professor of Pharmacology and Lineberger Comprehensive Cancer Center

Resource Faculty
Phone: 919-843-3257 | Office: 4093 Genetic Medicine Bldg.
Email: jmcalabr@med.unc.edu | Website: http://www.med.unc.edu/pharm/calabreselab

Research Areas: Bioinformatics, Comparative Genomics and Molecular Evolution, Computational Genomics
Research Interests: Sequence rules to predict long noncoding RNA function, mechanisms of transcriptional regulation by long noncoding RNAs


Ian Davis, MD, PhD

G. Denman Hammond Professor of Genetics and Pediatrics

Resource Faculty
Phone: (919) 966-5360 | Office: 21-219 Lineberger Comprehensive Cancer Center
Email: ian_davis@med.unc.edu | Website: http://davislab.web.unc.edu/

Research Areas: Computational Genomics, Bioinformatics
Research Interests: Epigenomic and transcriptomic consequences of genetic alterations in cancer and applications to therapeutic discovery.


Daniel Dominguez, PhD

Assistant Professor of Pharmacology

Resource Faculty
Phone: (919) 966-0131 | Office: 4113 Genetic Medicine Building
Email: didoming@email.unc.edu | Website: https://dominguez-lab.org/

Research Areas: Bioinformatics, Comparative Genomics and Molecular Evolution, Computational Genomics, Computational Systems Biology
Research Interests: The Dominguez lab studies how gene expression is controlled by proteins that bind RNA. We apply high-throughput biochemical and computational approaches to understand protein-RNA interactions, RNA processing, and gene regulation in normal and disease biology.


Jill Dowen, PhD

Assistant Professor of Biochemistry & Biophysics and Biology

Resource Faculty
Phone: 919-962-8132 | Office: 3360 Genome Sciences Building
Email: jilldowen@unc.edu | Website: http://jilldowenlab.web.unc.edu/

Research Areas: Bioinformatics, Computational Genomics, Chromosome Conformation
Research Interests: Our research program integrates the areas of transcriptional regulation, three-dimensional genome organization and functional genomics to understand how the architecture of the genome influences gene expression during development and disease.


Hector L Franco, PhD

Assistant Professor of Genetics; UNC Lineberger Cancer Center

Resource Faculty
Phone: (919) 966-5269 | Office: 5109 Marsico Hall
Email: hfranco@med.unc.edu | Website: https://www.thefrancolab.org/

Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology
Research Interests: The Franco lab has a long-standing interest in gene regulation, epigenetics, chromatin and RNA biology, especially as it pertains to cancer. We address these research aims by using an interdisciplinary approach that combines molecular and cellular techniques with functional genomic and computational approaches.


Shawn Gomez, Eng.Sc.D

Associate Professor of Joint Department of Biomedical Engineering at UNC-Chapel Hill and NC State University

Core Faculty
Phone: 919-966-4959 | Office: 144 MacNider Hall
Email: smgomez@unc.edu | Website: http://gomezlab.bme.unc.edu/

Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology, Image Analysis
Research Interests: Systems biology with emphases in cancer and infectious disease


Bradley Hemminger, PhD

Associate Professor of School of Information and Library Science

Core Faculty
Phone: 919-966-2998 | Office: 206A Manning Hall
Email: bmh@ils.unc.edu | Website: http://ils.unc.edu/bmh/

Research Areas: Bioinformatics
Research Interests: Bioinformatics, medical informatics, user interface design


Katherine Hoadley, PhD

Assistant Professor of Genetics

Resource Faculty
Phone: (919) 962-8416 | Office: 5212 Marsico Hall
Email: hoadley@med.unc.edu | Website: https://unclineberger.org/people/profiles/katherine-hoadley

Research Areas: Computational Genomics, Bioinformatics, Computational Systems Biology
Research Interests: My research interest is in genomic characterization and integrative genomic approaches to better understand cancer. My group is part of the NCI Genome Data Analysis Center focused on RNA expression analysis. We have a number of ongoing projects including developing molecular classifications for potential clinical utility, developing methods for deconvolution to understand bulk tissue heterogeneity, analysis of driver negative cancers, and analysis of ancestry markers with cancer features.


Corbin D. Jones, PhD

Associate Professor of Biology and Carolina Center for Genome Sciences

Core Faculty
Phone: 919-962-4443 | Office: 3159 Genome Science Bldg.
Email: cdjones@email.unc.edu | Website: http://bio.unc.edu/people/faculty/cdjones/

Research Areas: Bioinformatics, Comparative Genomics and Molecular Evolution, Statistical and Populational Genetics
Research Interests: Developing novel computational approaches for comparative analysis of genomics data


Alain Laederach, PhD

Assistant Professor of Biology

Core Faculty
Phone: 919-962-4565 | Office: 3354 Genome Sciences Bldg.
Email: alain@unc.edu | Website: http://ribosnitch.bio.unc.edu/The_Laederach_Lab/Welcome.html

Research Areas: Bioinformatics, Computational Genomics
Research Interests: RNA bioinformatics and transcriptomics


Yun Li, PhD

Associate Professor of Genetics and Biostatistics

Core Faculty
Phone: 919-843-1899 | Office: 5090 Genetic Medicine Bldg.
Email: yunli@med.unc.edu | Website: http://www.unc.edu/~yunmli/

Research Areas: Bioinformatics, Statistical and Populational Genetics
Research Interests: The focus of my research is on the development of statistical methods and their application to the genetic dissection of complex diseases and traits.


Yufeng Liu, PhD

Professor of Statistics & Operations Research, Biostatistcs, and Genetics

Resource Faculty
Phone: 919-962-4475 | Office: 4250 Genome Science Building
Email: yfliu@email.unc.edu | Website: http://www.unc.edu/~yfliu

Research Areas: Bioinformatics, Image Analysis, Statistical and Populational Genetics
Research Interests: Statistical Machine Learning and Data Mining; High-dimensional Data Analysis; Nonparametric Statistics and Functional Estimation; Bioinformatics; Cancer Genomics; Medical Imaging Data Analysis


Ben Major, PhD

Assistant Professor of Cell Biology and Physiology; Lineberger Comprehensive Cancer Center

Resource Faculty
Phone: 919-259-2695 | Office: Lineberger Comprehensive Cancer Center, Room 31-322
Email: benmajor@med.unc.edu | Website: http://cancer.unc.edu/majorlab/research.php

Research Areas: Bioinformatics, Computational Systems Biology
Research Interests: Computational proteomics and mass spectrometry. Network structure and dynamics of protein-protein interactions. Multi-OMIC integrations focused on signal transduction in cancer initiation and evolution.


Steve Marron, PhD

Amos Hawley Distinguished Professor of Statistics & Operations Research

Core Faculty
Phone: 919-962-2188 | Office: 352 Hanes Hall
Email: marron@unc.edu | Website: http://marron.web.unc.edu

Research Areas: Bioinformatics, Computational Genomics, Image Analysis
Research Interests: Statistical research on high dimensional, functional, and object oriented data analysis, and data visualization.


Daniel J. McKay, PhD

Assistant Professor of Biology and Genetics

Resource Faculty
Phone: 919-843-2064 | Office: 3358 Genome Sciences Bldg.
Email: dmckay1@email.unc.edu | Website: http://mckaylab.web.unc.edu

Research Areas: Bioinformatics, Computational Genomics
Research Interests: Genetic and epigenetic regulation of gene expression during development


C Ryan Miller, MD, PhD

Associate Professor of Pathology and Laboratory Medicine

Resource Faculty
Phone: (919) 966-4333 | Office: 6109B Neurosciences Research Building
Email: rmiller@med.unc.edu | Website: https://www.med.unc.edu/pathology/millerlab/

Research Areas: Bioinformatics, Computational Genomics
Research Interests: Development of novel mouse models of brain cancers and their comparative epigenomic, genomic, transcriptomic, and proteomic characterization relative to human tumors


Karen Mohlke, PhD

Professor of Genetics

Resource Faculty
Phone: 919-966-2913 | Office: 5096 Genetic Medicine Bldg.
Email: mohlke@med.unc.edu | Website: http://mohlke.web.unc.edu/

Research Areas: Bioinformatics, Computational Genomics, Statistical and Population Genetics
Research Interests: Genetic basis of complex metabolic traits


Peter J. Mucha, PhD

Bowman and Gordon Gray Distinguished Term Professor of Mathematics

Resource Faculty
Phone: 919-962-1294 | Office: 425 Chapman Hall
Email: mucha@unc.edu | Website: http://mucha.web.unc.edu/

Research Areas: Bioinformatics, Computational Systems Biology
Research Interests: Applied & Computational Mathematics, Networks, Complex Systems, Data Science


Joel Parker, PhD

Research Associate Professor of Genetics

Core Faculty
Phone: (919) 966-9614 | Office: 450 West Drive
Email: parkerjs@email.unc.edu | Website: https://lbc.unc.edu/

Research Areas: Bioinformatics, Computational Genomics
Research Interests: My research is focused in the methodological development and integrated analysis of high throughput genetic and genomic studies of cancer. Through the Lineberger Bioinformatics Shared Resource, we provide consultation and analytical services primarily for the Cancer Center, but are involved in collaborations across multiple departments and external institutions.


Charles M. Perou, PhD

The May Goldman Shaw Distinguished Professor of Molecular Oncology, of Genetics and Pathology & Laboratory Medicine

Core Faculty
Phone: 919-843-5740 | Office: 5111 Marsico Hall
Email: cperou@med.unc.edu | Website: http://peroulab.med.unc.edu/

Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology
Research Interests: The focus of the Perou Lab is to characterize the biological diversity of human tumors using genomics, genetics, and cell biology, and to then use this information to develop computational predictors of tumor responsiveness and patient outcomes. We use a variety of genomic data types including RNA-seq, DNA exomes/WGS, and DNA copy number data to build these objective models. A major focus of the lab is on novel algorithm development, and the translation of these genomic predictors into clinical assays for use on cancer patients.


Doug Phanstiel, PhD

Assistant Professor of Cell Biology & Physiology

Resource Faculty
Phone: 919-843-8847 | Office: 4019 Thurston Bowles Building
Email: douglas_phanstiel@med.unc.edu | Website: http://www.unc.edu/~dphansti/

Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology
Research Interests: We employ experimental and computational approaches to study the mechanisms through which enhancers and three-dimensional chromatin structure regulate gene transcription during cellular differentiation. The goals of our computational work include improved detection and quantification of three-dimensional chromatin structures and new tools for visualizing multi-dimensional genomic data.


Jan F. Prins, PhD

Professor of Computer Science

Core Faculty
Phone: 919-590-6213 | Office: FB334 Brooks Computer Science Building
Email: prins@cs.unc.edu | Website: http://www.cs.unc.edu/~prins/

Research Areas: Bioinformatics, Computational Biophysics, Computational Genomics
Research Interests: RNA sequencing and analysis; Parallel Computing


Jeremy Purvis, PhD

Assistant Professor of Genetics

Core Faculty
Phone: 919-962-4923 | Office: 5061 Genetic Medicine Bldg.
Email: jeremy_purvis@med.unc.edu | Website: http://genetics.unc.edu/purvislab/

Research Areas: Bioinformatics, Computational Systems Biology, Image Analysis
Research Interests: Our lab uses computational and experimental approaches to study signaling mechanisms in stem cells and cancer pathways. We are especially interested in understanding the molecular mechanisms underlying “irreversible” cell fate decisions such as apoptosis, senescence, and differentiation. We study the timing and mechanism of these decisions using a combination of time-lapse microscopy and computational modeling. Our ultimate goal is to not only understand how cells make decisions under physiological conditions, but to discover how to manipulate these decisions to treat disease.


Daniel Schrider, PhD

Assistant Professor of Genetics

Core Faculty
Phone: (919) 843-6475 | Office: 5111 Genetic Medicine Building
Email: dschride@email.unc.edu | Website: https://www.schriderlab.org/

Research Areas: Bioinformatics, Comparative Genomics and Molecular Evolution, Computational Genomics, Statistical and Population Genetics
Research Interests: We develop and apply computational tools to make inferences about evolution from population genomic datasets. Our research areas include the population genetics of adaptation, genomic copy number variants, and the application of supervised machine learning tools to evolutionary questions.


Shehzad Sheikh, MD, PhD

Associate Professor of Genetics and Medicine

Resource Faculty
Phone: (919) 966-0745 | Office: 7320 Medical Biomolecular Research Building
Email: sheisx@med.unc.edu | Website: http://sheikhlab.web.unc.edu/

Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology
Research Interests: We seek to understand how information is encoded and dynamically utilized in immune cells from healthy and disease prone intestines (Crohn’s disease and Ulcerative colitis). We focus specifically on genes that regulate response to the bacteria that normally reside in our intestines. We use genome-sequencing technology to precisely identify regions throughout the genome that are potential ‘on’ or ‘off’ switches for these genes.


John Sondek, PhD

Professor of Pharmacology, and Biochemistry & Biophysics

Resource Faculty
Phone: 919-966-7530 | Office: 4060 Genetic Medicine Bldg.
Email: sondek@med.unc.edu | Website: http://www.med.unc.edu/pharm/sondeklab

Research Areas: Bioinformatics, Computational Biophysics, Computational Systems Biology
Research Interests: Signaling networks controlled by GTPases; structural biology; chemical biology; biosensors design and use; cancer therapeutics


Jason Stein, PhD

Assistant Professor of Genetics

Core Faculty
Phone: (919) 843-5541 | Office: 8109C Neuroscience Research Bldg.
Email: jason_stein@med.unc.edu | Website: http://www.steinlab.org/

Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology
Research Interests: The focus of our research is finding and modeling genetic variants influencing human brain structure and function.


Brian Strahl, PhD

Professor and Vice-Chair of Biochemistry & Biophysics

Resource Faculty
Phone: (919) 843-3896 | Office: 3060 Genetic Medicine
Email: brian_strahl@med.unc.edu | Website: http://www.med.unc.edu/~bstrahl/

Research Areas: Bioinformatics, Computational Biophysics, Computational Genomics
Research Interests: Our lab is interested in the role that histone post-translational modifications have in chromatin biology. Specifically, we are studying how enzymes that ‘write’ and ‘read’ histone modifications contribute to the function of chromatin and DNA-templated functions like gene transcription. To do so, we are employing a range of model organisms (yeast to mammalian cells) and approaches (genomics, genetics, biochemistry, biophysics as well as proteomics) that, together, are elucidating how readers and writer enzymes function to sculpt the chromatin landscape and regulate gene transcription. Students who join our lab would be involved in multiple UNC collaborations (as well as have individual projects) that would provide wide exposure these model systems and techniques.


Benjamin Vincent, MD

Assistant Professor of Medicine, Division of Hematology/Oncology

Resource Faculty
Phone: 919-962-8412 | Office: 5206 Marsico Hall
Email: bgvincen@unch.unc.edu | Website:

Research Areas: Computational Immunology, Bioinformatics, Computational Genomics, Computational Systems Biology
Research Interests: Current research focuses on how immunogenomics features including T cell receptor and B cell receptor repertoire characteristics predict survival and response to immunotherapy in breast cancer, bladder cancer, and acute myeloid leukemia.


Todd Vision, PhD

Associate Professor of Biology and Adjunct Associate Professor of School of Information and Library Science

Core Faculty
Phone: 919-962-4479 | Office: 3155 Genome Sciences Bldg.
Email: tjv@bio.unc.edu | Website: https://visionlab.web.unc.edu/

Research Areas: Bioinformatics, Comparative Genomics and Molecular Evolution, Computational Genomics, Statistical and Populational Genetics
Research Interests: I am interested in computational, statistical and quantitative approaches to testing ideas about the processes governing the evolution of genetic systems, from changes in gene content to major morphological innovations and other complex traits.


Kevin M. Weeks, PhD

Kenan Distinguished Professor of Chemistry

Resource Faculty
Phone: 919-962-7486 | Office: 3258 Genome Sciences Building
Email: weeks@unc.edu | Website: http://www.chem.unc.edu/rna/

Research Areas: Bioinformatics, Computational Biophysics, Computational Genomics
Research Interests: Chemical Biology, Structural Biology, and Bioinformatics of the Transcriptome


Kirk Wilhelmsen, PhD

Professor of Genetics

Core Faculty
Phone: 919-966-1373 | Office: 5093 Genetic Medicine Bldg.
Email: kirk_wilhelmsen@med.unc.edu | Website: http://kirkwilhelmsen.web.unc.edu/

Research Areas: Bioinformatics; Comparative Genomics & Molecular Evolution; Computational Genomics; Statistical & Population Genetics
Research Interests: Dr Wilhelmsen leads a lab group in the Dept. of Genetics and a Computational Group at RENCI (www.renci.org). The labs groups effort in human genetics is focused on behavior and neurodegeneration by annotation of the human genome using data intensive strategies. The lab group has developed several new analytic techniques. The lab is intensively engaged in the development of molecular techniques to study epigenetic phenomena and gene expression in complex populations of cells. The RENCI bioinformatics groups provide data intensive informatics approaches to support multidisciplinary research projects at the three triangle campuses. The current focus of this activity is to support genomics research. The group develops and maintains pipelines to support medical genomics analysis.


Hyejung Won, PhD

Assistant Professor of Department of Genetics

Core Faculty
Phone: (919) 966-4069 | Office: 7109A NRB
Email: hyejung_won@med.unc.edu | Website: http://www.wonlab.org/

Research Areas: Bioinformatics, Statistical and Population Genetics
Research Interests: We try to bridge the gap between genetic risk factors for psychiatric illnesses and neurobiological mechanisms by decoding the regulatory relationships in human brain. In particular, we implement Hi-C, a genome-wide chromosome conformation capture technique, to identify the folding principle of the genome in human brain. We then leverage this information to identify the functional impacts of the common variants associated with neuropsychiatric disorders.


Di Wu, PhD

Assistant Professor of Periodontics, School of Dentistry; Biostatistics

Resource Faculty
Phone: 919-537-3277 | Office: 4504 Koury Oral Health Sciences Building
Email: dwu@unc.edu | Website: http://sph.unc.edu/adv_profile/di-wu-phd/

Research Areas: Bioinformatics, Computational Genomics, Computational System Biology, Statistical and Population Genetics​
Research Interests: Development of statistical methods for multidimensional genomic data integration to understand the biological mechanism of diseases.


Mark Zylka, PhD

Associate Professor of UNC Neuroscience Center, Dept. of Cell Biology & Physiology

Resource Faculty
Phone: 919-966-2540 | Office: 5109 D Neuroscience Research Building
Email: zylka@med.unc.edu | Website: https://www.med.unc.edu/cellbiophysio/faculty/zylka

Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology, Image Analysis
Research Interests: Use of genome-wide approaches to study transcriptional regulators linked to autism; Use of RNA-seq and targeted sequencing to identify chemical risk factors for brain disorders (autism, brain aging, neurodegeneration, ADHD); Transcriptional mechanisms associated with long genes