Daniel Dominguez, PhD
Assistant Professor of Pharmacology
Research Areas: Bioinformatics, Comparative Genomics and Molecular Evolution, Computational Genomics, Computational Systems Biology
Research Interests: The Dominguez lab studies how gene expression is controlled by proteins that bind RNA. We apply high-throughput biochemical and computational approaches to understand protein-RNA interactions, RNA processing, and gene regulation in normal and disease biology.
Brian Strahl, PhD
Professor and Vice-Chair of Biochemistry & Biophysics
Research Areas: Bioinformatics, Computational Biophysics, Computational Genomics
Research Interests: Our lab is interested in the role that histone post-translational modifications have in chromatin biology. Specifically, we are studying how enzymes that ‘write’ and ‘read’ histone modifications contribute to the function of chromatin and DNA-templated functions like gene transcription. To do so, we are employing a range of model organisms (yeast to mammalian cells) and approaches (genomics, genetics, biochemistry, biophysics as well as proteomics) that, together, are elucidating how readers and writer enzymes function to sculpt the chromatin landscape and regulate gene transcription. Students who join our lab would be involved in multiple UNC collaborations (as well as have individual projects) that would provide wide exposure these model systems and techniques.
Daniel Schrider, PhD
Assistant Professor of Genetics
Research Areas: Bioinformatics, Comparative Genomics and Molecular Evolution, Computational Genomics, Statistical and Population Genetics
Research Interests: We develop and apply computational tools to make inferences about evolution from population genomic datasets. Our research areas include the population genetics of adaptation, genomic copy number variants, and the application of supervised machine learning tools to evolutionary questions.
Cavin Ward-Caviness, PhD
Computational Biologist/Principal Investigator of US EPA
Research Areas: Computational Genomics, Statistical and Population Genetics
Research Interests: My primary research interest is in using large clinical databases to uncover environmental and social health risks. In addition I am interested in furthering the use of machine learning in environmental epidemiology and uncovering molecular biomarkers for environmental health risk and the molecular mechanisms by which environmental exposures are translated into health outcomes.
Martin Ferris, PhD
Associate Professor of Genetics
Phone: (919) 966-4026 | Office: 5081 Genetic Medicine Building
Email: email@example.com | Website: https://www.linkedin.com/in/martin-ferris-63a32634/
Shehzad Sheikh, MD, PhD
Associate Professor of Genetics and Medicine
Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology
Research Interests: We seek to understand how information is encoded and dynamically utilized in immune cells from healthy and disease prone intestines (Crohn’s disease and Ulcerative colitis). We focus specifically on genes that regulate response to the bacteria that normally reside in our intestines. We use genome-sequencing technology to precisely identify regions throughout the genome that are potential ‘on’ or ‘off’ switches for these genes.
Ian Davis, MD, PhD
G. Denman Hammond Professor of Genetics and Pediatrics
Research Areas: Computational Genomics, Bioinformatics
Research Interests: Epigenomic and transcriptomic consequences of genetic alterations in cancer and applications to therapeutic discovery.
Katherine Hoadley, PhD
Assistant Professor of Genetics
Phone: (919) 962-8416 | Office: 5212 Marsico Hall
Email: firstname.lastname@example.org | Website: https://unclineberger.org/people/profiles/katherine-hoadley
Research Areas: Computational Genomics, Bioinformatics, Computational Systems Biology
Research Interests: My research interest is in genomic characterization and integrative genomic approaches to better understand cancer. My group is part of the NCI Genome Data Analysis Center focused on RNA expression analysis. We have a number of ongoing projects including developing molecular classifications for potential clinical utility, developing methods for deconvolution to understand bulk tissue heterogeneity, analysis of driver negative cancers, and analysis of ancestry markers with cancer features.
Hyejung Won, PhD
Assistant Professor of Department of Genetics
Research Areas: Bioinformatics, Statistical and Population Genetics
Research Interests: We try to bridge the gap between genetic risk factors for psychiatric illnesses and neurobiological mechanisms by decoding the regulatory relationships in human brain. In particular, we implement Hi-C, a genome-wide chromosome conformation capture technique, to identify the folding principle of the genome in human brain. We then leverage this information to identify the functional impacts of the common variants associated with neuropsychiatric disorders.