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Research Area: Bioinformatics

Daniel Dominguez, PhD

September 17, 2018

Daniel Dominguez, PhD

Assistant Professor of Pharmacology

Core Faculty
Phone: (919) 966-0131 | Office: 4113 Genetic Medicine Building
Email: didoming@email.unc.edu | Website: https://dominguez-lab.org/

Research Areas: Bioinformatics, Comparative Genomics and Molecular Evolution, Computational Genomics, Computational Systems Biology
Research Interests: The Dominguez lab studies how gene expression is controlled by proteins that bind RNA. We apply high-throughput biochemical and computational approaches to understand protein-RNA interactions, RNA processing, and gene regulation in normal and disease biology.

Brian Strahl, PhD

August 31, 2018

Brian Strahl, PhD

Professor and Vice-Chair of Biochemistry & Biophysics

Resource Faculty
Phone: (919) 843-3896 | Office: 3060 Genetic Medicine
Email: brian_strahl@med.unc.edu | Website: http://www.med.unc.edu/~bstrahl/

Research Areas: Bioinformatics, Computational Biophysics, Computational Genomics
Research Interests: Our lab is interested in the role that histone post-translational modifications have in chromatin biology. Specifically, we are studying how enzymes that ‘write’ and ‘read’ histone modifications contribute to the function of chromatin and DNA-templated functions like gene transcription. To do so, we are employing a range of model organisms (yeast to mammalian cells) and approaches (genomics, genetics, biochemistry, biophysics as well as proteomics) that, together, are elucidating how readers and writer enzymes function to sculpt the chromatin landscape and regulate gene transcription. Students who join our lab would be involved in multiple UNC collaborations (as well as have individual projects) that would provide wide exposure these model systems and techniques.

Daniel Schrider, PhD

August 30, 2018

Daniel Schrider, PhD

Assistant Professor of Genetics

Core Faculty
Phone: (919) 843-6475 | Office: 5111 Genetic Medicine Building
Email: dschride@email.unc.edu | Website: https://www.schriderlab.org/

Research Areas: Bioinformatics, Comparative Genomics and Molecular Evolution, Computational Genomics, Statistical and Population Genetics
Research Interests: We develop and apply computational tools to make inferences about evolution from population genomic datasets. Our research areas include the population genetics of adaptation, genomic copy number variants, and the application of supervised machine learning tools to evolutionary questions.

Shehzad Sheikh, MD, PhD

August 30, 2018

Shehzad Sheikh, MD, PhD

Associate Professor of Genetics and Medicine

Resource Faculty
Phone: (919) 966-0745 | Office: 7320 Medical Biomolecular Research Building
Email: sheisx@med.unc.edu | Website: http://sheikhlab.web.unc.edu/

Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology
Research Interests: We seek to understand how information is encoded and dynamically utilized in immune cells from healthy and disease prone intestines (Crohn’s disease and Ulcerative colitis). We focus specifically on genes that regulate response to the bacteria that normally reside in our intestines. We use genome-sequencing technology to precisely identify regions throughout the genome that are potential ‘on’ or ‘off’ switches for these genes.

Ian Davis, MD, PhD

August 29, 2018

Ian Davis, MD, PhD

G. Denman Hammond Professor of Genetics and Pediatrics

Resource Faculty
Phone: (919) 966-5360 | Office: 21-219 Lineberger Comprehensive Cancer Center
Email: ian_davis@med.unc.edu | Website: http://davislab.web.unc.edu/

Research Areas: Computational Genomics, Bioinformatics
Research Interests: Epigenomic and transcriptomic consequences of genetic alterations in cancer and applications to therapeutic discovery.

Katherine A. Hoadley, PhD

August 21, 2018

Katherine Hoadley, PhD

Assistant Professor of Genetics

Core Faculty
Phone: (919) 962-8416 | Office: 5212 Marsico Hall
Email: hoadley@med.unc.edu | Website: https://unclineberger.org/people/profiles/katherine-hoadley

Research Areas: Computational Genomics, Bioinformatics, Computational Systems Biology
Research Interests: My research interest is in genomic characterization and integrative genomic approaches to better understand cancer. My group is part of the NCI Genome Data Analysis Center focused on RNA expression analysis. We have a number of ongoing projects including developing molecular classifications for potential clinical utility, developing methods for deconvolution to understand bulk tissue heterogeneity, analysis of driver negative cancers, and analysis of ancestry markers with cancer features.

Hyejung Won

August 13, 2018

Hyejung Won, PhD

Assistant Professor of Department of Genetics

Core Faculty
Phone: (919) 966-4069 | Office: 7202B Mary Ellen Jones Building, 116 Manning Dr.
Email: hyejung_won@med.unc.edu | Website: http://www.wonlab.org/

Research Areas: Bioinformatics, Statistical and Population Genetics
Research Interests: We try to bridge the gap between genetic risk factors for psychiatric illnesses and neurobiological mechanisms by decoding the regulatory relationships in human brain. In particular, we implement Hi-C, a genome-wide chromosome conformation capture technique, to identify the folding principle of the genome in human brain. We then leverage this information to identify the functional impacts of the common variants associated with neuropsychiatric disorders.

Hector Franco

June 5, 2018

Hector L Franco, PhD

Assistant Professor of Genetics; UNC Lineberger Cancer Center

Core Faculty
Phone: (919) 966-5269 | Office: 5109 Marsico Hall
Email: hfranco@med.unc.edu | Website: https://www.thefrancolab.org/

Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology
Research Interests: The Franco lab has a long-standing interest in gene regulation, epigenetics, chromatin and RNA biology, especially as it pertains to cancer. We address these research aims by using an interdisciplinary approach that combines molecular and cellular techniques with functional genomic and computational approaches.

Doug Phanstiel, PhD

February 9, 2018

Doug Phanstiel, PhD

Assistant Professor of Cell Biology & Physiology

Resource Faculty
Phone: 919-843-8847 | Office: 4019 Thurston Bowles Building
Email: douglas_phanstiel@med.unc.edu | Website: http://www.unc.edu/~dphansti/

Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology
Research Interests: We employ experimental and computational approaches to study the mechanisms through which enhancers and three-dimensional chromatin structure regulate gene transcription during cellular differentiation. The goals of our computational work include improved detection and quantification of three-dimensional chromatin structures and new tools for visualizing multi-dimensional genomic data.

Jill Dowen

November 28, 2017

Jill Dowen, PhD

Assistant Professor of Biochemistry & Biophysics and Biology

Resource Faculty
Phone: 919-962-8132 | Office: 3360 Genome Sciences Building
Email: jilldowen@unc.edu | Website: http://jilldowenlab.web.unc.edu/

Research Areas: Bioinformatics, Computational Genomics, Chromosome Conformation
Research Interests: Our research program integrates the areas of transcriptional regulation, three-dimensional genome organization and functional genomics to understand how the architecture of the genome influences gene expression during development and disease.