Daniel Dominguez, PhD
Daniel Dominguez, PhD
Assistant Professor of
Pharmacology
Core Faculty
Phone: (919) 966-0131 | Office: 4113 Genetic Medicine Building
Email: didoming@email.unc.edu | Website: https://dominguez-lab.org/
Research Areas: Bioinformatics, Comparative Genomics and Molecular Evolution, Computational Genomics, Computational Systems Biology
Research Interests: The Dominguez lab studies how gene expression is controlled by proteins that bind RNA. We apply high-throughput biochemical and computational approaches to understand protein-RNA interactions, RNA processing, and gene regulation in normal and disease biology.
Brian Strahl, PhD
Brian Strahl, PhD
Professor and Vice-Chair of
Biochemistry & Biophysics
Resource Faculty
Phone: (919) 843-3896 | Office: 3060 Genetic Medicine
Email: brian_strahl@med.unc.edu | Website: http://www.med.unc.edu/~bstrahl/
Research Areas: Bioinformatics, Computational Biophysics, Computational Genomics
Research Interests: Our lab is interested in the role that histone post-translational modifications have in chromatin biology. Specifically, we are studying how enzymes that ‘write’ and ‘read’ histone modifications contribute to the function of chromatin and DNA-templated functions like gene transcription. To do so, we are employing a range of model organisms (yeast to mammalian cells) and approaches (genomics, genetics, biochemistry, biophysics as well as proteomics) that, together, are elucidating how readers and writer enzymes function to sculpt the chromatin landscape and regulate gene transcription. Students who join our lab would be involved in multiple UNC collaborations (as well as have individual projects) that would provide wide exposure these model systems and techniques.
Daniel Schrider, PhD
Daniel Schrider, PhD
Associate Professor of
Genetics
Core Faculty
Phone: (919) 843-6475 | Office: 5047 Genetic Medicine Building
Email: dschride@email.unc.edu | Website: https://www.schriderlab.org/
Research Areas: Bioinformatics, Comparative Genomics and Molecular Evolution, Computational Genomics, Statistical and Population Genetics
Research Interests: We develop and apply computational tools to make inferences about evolution from population genomic datasets. Our research areas include the population genetics of adaptation, genomic copy number variants, and the application of supervised machine learning tools to evolutionary questions.
Shehzad Sheikh, MD, PhD
Shehzad Sheikh, MD, PhD
Associate Professor of
Genetics and Medicine
Resource Faculty
Phone: (919) 966-0745 | Office: 7320 Medical Biomolecular Research Building
Email: sheisx@med.unc.edu | Website: http://sheikhlab.web.unc.edu/
Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology
Research Interests: We seek to understand how information is encoded and dynamically utilized in immune cells from healthy and disease prone intestines (Crohn’s disease and Ulcerative colitis). We focus specifically on genes that regulate response to the bacteria that normally reside in our intestines. We use genome-sequencing technology to precisely identify regions throughout the genome that are potential ‘on’ or ‘off’ switches for these genes.
Ian Davis, MD, PhD
Ian Davis, MD, PhD
G. Denman Hammond Professor of
Genetics and Pediatrics
Resource Faculty
Phone: (919) 966-5360 | Office: 21-219 Lineberger Comprehensive Cancer Center
Email: ian_davis@med.unc.edu | Website: http://davislab.web.unc.edu/
Research Areas: Computational Genomics, Bioinformatics
Research Interests: Epigenomic and transcriptomic consequences of genetic alterations in cancer and applications to therapeutic discovery.
Katherine A. Hoadley, PhD
Katherine Hoadley, PhD
Associate Professor of
Genetics
Core Faculty
Phone: (919) 962-8416 | Office: 11-212 Mary Ellen Jones Building
Email: hoadley@med.unc.edu | Website: https://unclineberger.org/people/profiles/katherine-hoadley
Research Areas: Computational Genomics, Bioinformatics, Computational Systems Biology
Research Interests: My research interest is in genomic characterization and integrative genomic approaches to better understand cancer. My group is part of the NCI Genome Data Analysis Center focused on RNA expression analysis. We have a number of ongoing projects including developing molecular classifications for potential clinical utility, developing methods for deconvolution to understand bulk tissue heterogeneity, analysis of driver negative cancers, and analysis of ancestry markers with cancer features.
Hyejung Won
Hyejung Won, PhD
Assistant Professor of
Department of Genetics
Core Faculty
Phone: (919) 966-4069 | Office: 7202B Mary Ellen Jones Building, 116 Manning Dr.
Email: hyejung_won@med.unc.edu | Website: http://www.wonlab.org/
Research Areas: Bioinformatics, Statistical and Population Genetics
Research Interests: We try to bridge the gap between genetic risk factors for psychiatric illnesses and neurobiological mechanisms by decoding the regulatory relationships in human brain. In particular, we implement Hi-C, a genome-wide chromosome conformation capture technique, to identify the folding principle of the genome in human brain. We then leverage this information to identify the functional impacts of the common variants associated with neuropsychiatric disorders.
Doug Phanstiel, PhD
Doug Phanstiel, PhD
Assistant Professor of
Cell Biology & Physiology
Core Faculty
Phone: 919-843-8847 | Office: 4019 Thurston Bowles Building
Email: douglas_phanstiel@med.unc.edu | Website: http://www.unc.edu/~dphansti/
Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology
Research Interests: We employ experimental and computational approaches to study the mechanisms through which enhancers and three-dimensional chromatin structure regulate gene transcription during cellular differentiation. The goals of our computational work include improved detection and quantification of three-dimensional chromatin structures and new tools for visualizing multi-dimensional genomic data.
Jill Dowen
Jill Dowen, PhD
Associate Professor of
Biochemistry & Biophysics and Biology
Resource Faculty
Phone: 919-962-8132 | Office: 3360 Genome Sciences Building
Email: jilldowen@unc.edu | Website: http://jilldowenlab.web.unc.edu/
Research Areas: Bioinformatics, Computational Genomics, Chromosome Conformation
Research Interests: Our research program integrates the areas of transcriptional regulation, three-dimensional genome organization and functional genomics to understand how the architecture of the genome influences gene expression during development and disease.
Michael Love
Michael Love, PhD
Associate Professor of
Genetics and Biostatistics
Core Faculty
Phone: (919) 966-7266 | Office: 5009 GMB
Email: milove@email.unc.edu | Website: https://mikelove.github.io
Research Areas: Bioinformatics, Computational Genomics, Statistical and Populational Genetics
Research Interests: The Love lab develops statistical and computational methods for the analysis of high-dimensional genomic data for biomedical and biological research. The Love lab has developed a number of open source software packages for the analysis of genomic datasets in R/Bioconductor.