Charles M. Perou, PhD
Charles M. Perou, PhD
The May Goldman Shaw Distinguished Professor of Molecular Oncology, of
Genetics and Pathology & Laboratory Medicine
Core Faculty
Phone: 919-843-5740 | Office: 5111 Marsico Hall
Email: cperou@med.unc.edu | Website: http://peroulab.med.unc.edu/
Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology
Research Interests: The focus of the Perou Lab is to characterize the biological diversity of human tumors using genomics, genetics, and cell biology, and to then use this information to develop computational predictors of tumor responsiveness and patient outcomes. We use a variety of genomic data types including RNA-seq, DNA exomes/WGS, and DNA copy number data to build these objective models. A major focus of the lab is on novel algorithm development, and the translation of these genomic predictors into clinical assays for use on cancer patients.
Steve Marron, PhD
Steve Marron, PhD
Amos Hawley Distinguished Professor of
Statistics & Operations Research
Core Faculty
Phone: 919-962-2188 | Office: 352 Hanes Hall
Email: marron@unc.edu | Website: http://marron.web.unc.edu
Research Areas: Bioinformatics, Computational Genomics, Image Analysis
Research Interests: Statistical research on high dimensional, functional, and object oriented data analysis, and data visualization.
Yufeng Liu, PhD
Yufeng Liu, PhD
Professor of
Statistics & Operations Research, Biostatistics, and Genetics
Resource Faculty
Phone: 919-962-4475 | Office: 4250 Genome Science Building
Email: yfliu@email.unc.edu | Website: http://www.unc.edu/~yfliu
Research Areas: Bioinformatics, Image Analysis, Statistical and Populational Genetics
Research Interests: Statistical Machine Learning and Data Mining; High-dimensional Data Analysis; Nonparametric Statistics and Functional Estimation; Bioinformatics; Cancer Genomics; Medical Imaging Data Analysis
Shawn Gomez, Eng.Sc.D
Shawn Gomez, Eng.Sc.D
Professor of
Joint Department of Biomedical Engineering at UNC-Chapel Hill and NC State University
Core Faculty
Phone: 919-966-4959 | Office: 144 MacNider Hall
Email: smgomez@unc.edu | Website: http://gomezlab.bme.unc.edu/
Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology, Image Analysis
Research Interests: Systems biology with emphases in cancer and infectious disease
Yun Li, PhD
Yun Li, PhD
Professor of
Genetics and Biostatistics
Core Faculty
Phone: 919-843-2832 | Office: 5043 Genetic Medicine Building
Email: yunli@med.unc.edu | Website: https://yunliweb.its.unc.edu
Research Areas: Bioinformatics, Statistical and Populational Genetics
Research Interests: The focus of my research is on the development of statistical methods and their application to the genetic dissection of complex diseases and traits.
Alain Laederach, PhD
Alain Laederach, PhD
Professor of
Biology
Core Faculty
Phone: 919-962-4565 | Office: 3354 Genome Sciences Bldg.
Email: alain@unc.edu | Website: http://ribosnitch.bio.unc.edu/The_Laederach_Lab/Welcome.html
Research Areas: Bioinformatics, Computational Genomics
Research Interests: RNA bioinformatics and transcriptomics
Karen Mohlke, PhD
Karen Mohlke, PhD
Professor of
Genetics
Resource Faculty
Phone: 919-966-2913 | Office: 5096 Genetic Medicine Bldg.
Email: mohlke@med.unc.edu | Website: http://mohlke.web.unc.edu/
Research Areas: Bioinformatics, Computational Genomics, Statistical and Population Genetics
Research Interests: Genetic basis of complex metabolic traits
Jeremy Purvis, PhD
Jeremy Purvis, PhD
Professor and Associate Chair for Education of
Genetics
Core Faculty
Phone: 919-962-4923 | Office: 11018C Mary Ellen Jones Building
Email: jeremy_purvis@med.unc.edu | Website: http://genetics.unc.edu/purvislab/
Research Areas: Bioinformatics, Computational Systems Biology, Image Analysis
Research Interests: Our lab uses computational and experimental approaches to study signaling mechanisms in stem cells and cancer pathways. We are especially interested in understanding the molecular mechanisms underlying “irreversible” cell fate decisions such as apoptosis, senescence, and differentiation. We study the timing and mechanism of these decisions using a combination of time-lapse microscopy and computational modeling. Our ultimate goal is to not only understand how cells make decisions under physiological conditions, but to discover how to manipulate these decisions to treat disease.
J. Mauro Calabrese, PhD
J. Mauro Calabrese, PhD
Associate Professor of
Pharmacology and Lineberger Comprehensive Cancer Center
Resource Faculty
Phone: 919-843-3257 | Office: 4093 Genetic Medicine Building
Email: jmcalabr@med.unc.edu | Website: http://www.med.unc.edu/pharm/calabreselab
Research Areas: Bioinformatics, Comparative Genomics and Molecular Evolution, Computational Genomics
Research Interests: Sequence rules to predict long noncoding RNA function, mechanisms of transcriptional regulation by long noncoding RNAs