Pew-Thian Yap, PhD
Pew-Thian Yap, PhD
Professor of
Radiology
Core Faculty
Phone: (919) 843-8712 | Office: 3117 Bioinformatics Building
Email: ptyap@med.unc.edu | Website: https://www.yaplab.io/
Research Areas: Image Analysis, Bioinformatics, Computational Biophysics, Computational Systems Biology
Research Interests: Image acquisition, reconstruction, quality control, harmonization, processing, and analysis with application to neuroscience.
Elisa Pieri, PhD
Elisa Pieri, PhD
Assistant Professor of
Chemistry
Core Faculty
Phone: 919-962-1619 | Office: 118 Caudill Labs
Email: elipieri@unc.edu | Website: https://www.pierilab.com/
Research Areas: Computational Biophysics
Research Interests: We seek to understand, predict and tune the events triggered by photon absorption in small biomimetic molecules and proteins, and develop rational design principles to build bio-imaging and optogenetics agents. In particular, we focus on tuning the fluorescence and photochromic properties of molecules and proteins using computational photoreaction discovery techniques. Note: recommend students taking Chem 495 if you are interested in the Pieri group.
Yinglong Miao
Yinglong Miao, PhD
Associate Professor of
Pharmacology and Computational Medicine
Core Faculty
Phone: 919-962-5696 | Office: 11004C Mary Ellen Jones Building
Email: yinglong_miao@med.unc.edu | Website: http://miaolab.org/
Research Areas: Bioinformatics, Computational Biophysics, Image Analysis
Research Interests: Dr. Miao develops novel theoretical and computational methods and Deep Learning techniques, which speed up molecular simulations by orders of magnitude, and applies these methods for unprecedented simulations of biomolecular dynamics and cellular signaling events. In collaboration with leading experimentalists, the Miao Lab combines complementary simulations and experiments to uncover functional mechanisms and design drugs of important biomolecules, including G-protein-coupled receptors (GPCRs), membrane-embedded proteases, RNA-binding proteins and RNA.
Karin Leiderman
Karin Leiderman, PhD
Associate Professor of
Mathematics
Core Faculty
Phone: 919-962-5962 | Office: Mary Ellen Jones Building 11212A
Email: karinlg@unc.edu | Website: https://sites.google.com/view/leiderman-research-group
Research Areas: Computational Biophysics, Computational Systems Biology
Research Interests: I am a mathematical biologist interested in the biochemical and biophysical aspects of blood clotting and emergent behavior in biological fluid-structure interaction problems. I especially love mathematical modeling, where creativity, biological knowledge, and mathematical insight meet. My research typically includes the integration of mathematical and experimental approaches together with statistical analyses and inference, to determine mechanisms underlying complex biological phenomena.
Wesley R Legant, PhD
Wesley R Legant, PhD
Joint Assistant Professor of
Biomedical Engineering and Pharmacology
Resource Faculty
Phone: (919) 966-4816 | Office: 4047 Genetic Medicine Building
Email: legantw@email.unc.edu | Website: https://www.med.unc.edu/pharm/people/primaryfaculty/wesley-r-legant/wesley-r-legant
Research Areas: Computational Biophysics, Image Analysis
Research Interests: Microscopy, 3D image analysis, biomaterials, cell migration, cancer metastasis, tissue engineering
Ehssan Nazockdast, PhD
Ehssan Nazockdast, PhD
Assistant Professor of
Applied Physical Science
Resource Faculty
Phone: (919) 962-5097 | Office:
Email: ehssan@email.unc.edu | Website: http://nazockdastlab.com/
Research Areas: Computational Biophsyics
Research Interests:
Brian Strahl, PhD
Brian Strahl, PhD
Professor and Vice-Chair of
Biochemistry & Biophysics
Resource Faculty
Phone: (919) 843-3896 | Office: 3060 Genetic Medicine
Email: brian_strahl@med.unc.edu | Website: http://www.med.unc.edu/~bstrahl/
Research Areas: Bioinformatics, Computational Biophysics, Computational Genomics
Research Interests: Our lab is interested in the role that histone post-translational modifications have in chromatin biology. Specifically, we are studying how enzymes that ‘write’ and ‘read’ histone modifications contribute to the function of chromatin and DNA-templated functions like gene transcription. To do so, we are employing a range of model organisms (yeast to mammalian cells) and approaches (genomics, genetics, biochemistry, biophysics as well as proteomics) that, together, are elucidating how readers and writer enzymes function to sculpt the chromatin landscape and regulate gene transcription. Students who join our lab would be involved in multiple UNC collaborations (as well as have individual projects) that would provide wide exposure these model systems and techniques.
John Sondek, PhD
John Sondek, PhD
Professor of
Pharmacology, and Biochemistry & Biophysics
Resource Faculty
Phone: 919-966-7530 | Office: 4060 Genetic Medicine Bldg.
Email: sondek@med.unc.edu | Website: http://www.med.unc.edu/pharm/sondeklab
Research Areas: Bioinformatics, Computational Biophysics, Computational Systems Biology
Research Interests: Signaling networks controlled by GTPases; structural biology; chemical biology; biosensors design and use; cancer therapeutics
Jan F. Prins, PhD
Jan F. Prins, PhD
Professor of
Computer Science
Core Faculty
Phone: 919-590-6213 | Office: FB334 Brooks Computer Science Building
Email: prins@cs.unc.edu | Website: http://www.cs.unc.edu/~prins/
Research Areas: Bioinformatics, Computational Biophysics, Computational Genomics
Research Interests: RNA sequencing and analysis; Parallel Computing
Flavio Frohlich, PhD
Flavio Frohlich, PhD
Professor of
Psychiatry, Cell Biology and Physiology, Biomedical Engineering, Neurology
Core Faculty
Phone: 919-966-4584 | Office: 4109F Neurosciences Research Bldg.
Email: flavio_frohlich@med.unc.edu | Website: http://www.frohlichlab.org
Research Areas: Computational Biophysics
Research Interests: Our goal is to revolutionize the treatment of psychiatric and neurological illness by developing novel brain stimulation paradigms. We identify and target network dynamics of physiological and pathological brain function. We combine computational modeling, optogenetics, in vitro and in vivo electrophysiology in animal models and humans, control engineering, and clinical trials. We strive to make our laboratory a productive, collaborative, and happy workplace.