Benjamin Vincent, MD
Benjamin Vincent, MD
Associate Professor of
Medicine, Division of Hematology/Oncology
Resource Faculty
Phone: 919-962-8412 | Office: 5206 Marsico Hall
Email: bgvincen@unch.unc.edu | Website:
Research Areas: Computational Immunology, Bioinformatics, Computational Genomics, Computational Systems Biology
Research Interests: Current research focuses on how immunogenomics features including T cell receptor and B cell receptor repertoire characteristics predict survival and response to immunotherapy in breast cancer, bladder cancer, and acute myeloid leukemia.
Jason Stein, PhD
Jason Stein, PhD
Associate Professor of
Genetics & Neuroscience Research Center
Core Faculty
Phone: (919) 843-5541 | Office: 7202A Mary Ellen Jones Building
Email: jason_stein@med.unc.edu | Website: http://www.steinlab.org/
Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology
Research Interests: The focus of our research is finding and modeling genetic variants influencing human brain structure and function.
Henrik G. Dohlman, PhD
Henrik G. Dohlman, PhD
Professor of
Pharmacology and Biochemistry & Biophysics
Resource Faculty
Phone: 919-843-6894 | Office: 3046 Genetic Medicine Bldg.
Email: hdohlman@med.unc.edu | Website: http://www.med.unc.edu/~hdohlman/
Research Areas: Computational Systems Biology
Research Interests: Regulation of G protein signaling
John Sondek, PhD
John Sondek, PhD
Professor of
Pharmacology, and Biochemistry & Biophysics
Resource Faculty
Phone: 919-966-7530 | Office: 4060 Genetic Medicine Bldg.
Email: sondek@med.unc.edu | Website: http://www.med.unc.edu/pharm/sondeklab
Research Areas: Bioinformatics, Computational Biophysics, Computational Systems Biology
Research Interests: Signaling networks controlled by GTPases; structural biology; chemical biology; biosensors design and use; cancer therapeutics
Mark Zylka, PhD
Mark Zylka, PhD
Professor of
UNC Neuroscience Center, Dept. of Cell Biology & Physiology
Resource Faculty
Phone: 919-966-2540 | Office: 5109 D Neuroscience Research Building
Email: zylka@med.unc.edu | Website: https://www.med.unc.edu/cellbiophysio/faculty/zylka
Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology, Image Analysis
Research Interests: Use of genome-wide approaches to study transcriptional regulators linked to autism; Use of RNA-seq and targeted sequencing to identify chemical risk factors for brain disorders (autism, brain aging, neurodegeneration, ADHD); Transcriptional mechanisms associated with long genes
Charles M. Perou, PhD
Charles M. Perou, PhD
The May Goldman Shaw Distinguished Professor of Molecular Oncology, of
Genetics and Pathology & Laboratory Medicine
Core Faculty
Phone: 919-843-5740 | Office: 5111 Marsico Hall
Email: cperou@med.unc.edu | Website: http://peroulab.med.unc.edu/
Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology
Research Interests: The focus of the Perou Lab is to characterize the biological diversity of human tumors using genomics, genetics, and cell biology, and to then use this information to develop computational predictors of tumor responsiveness and patient outcomes. We use a variety of genomic data types including RNA-seq, DNA exomes/WGS, and DNA copy number data to build these objective models. A major focus of the lab is on novel algorithm development, and the translation of these genomic predictors into clinical assays for use on cancer patients.
Shawn Gomez, Eng.Sc.D
Shawn Gomez, Eng.Sc.D
Professor of
Joint Department of Biomedical Engineering at UNC-Chapel Hill and NC State University
Core Faculty
Phone: 919-966-4959 | Office: 144 MacNider Hall
Email: smgomez@unc.edu | Website: http://gomezlab.bme.unc.edu/
Research Areas: Bioinformatics, Computational Genomics, Computational Systems Biology, Image Analysis
Research Interests: Systems biology with emphases in cancer and infectious disease
Jeremy Purvis, PhD
Jeremy Purvis, PhD
Professor and Associate Chair for Education of
Genetics
Core Faculty
Phone: 919-962-4923 | Office: 11018C Mary Ellen Jones Building
Email: jeremy_purvis@med.unc.edu | Website: http://genetics.unc.edu/purvislab/
Research Areas: Bioinformatics, Computational Systems Biology, Image Analysis
Research Interests: Our lab uses computational and experimental approaches to study signaling mechanisms in stem cells and cancer pathways. We are especially interested in understanding the molecular mechanisms underlying “irreversible” cell fate decisions such as apoptosis, senescence, and differentiation. We study the timing and mechanism of these decisions using a combination of time-lapse microscopy and computational modeling. Our ultimate goal is to not only understand how cells make decisions under physiological conditions, but to discover how to manipulate these decisions to treat disease.
Klaus Hahn, PhD
Klaus Hahn, PhD
Distinguished Professor of
Pharmacology; Chemical Biology & Medicinal Chemistry
Resource Faculty
Phone: 919-843-2775 | Office: 4043 Genetic Medicine Bldg.
Email: khahn@med.unc.edu | Website: http://www.hahnlab.com
Research Areas: Computational Biophysics, Computational Systems Biology, Image Analysis
Research Interests: visualization and control of protein function in living cells and animals, using protein engineering and small molecule synthesis; signaling dynamics; motility, megakaryocyte and immune cell function
Terry Furey, PhD
Terry Furey, PhD
Professor of
Genetics and Biology
Core Faculty
Phone: 919-966-7033 | Office: 5022 Genetic Medicine Bldg.
Email: tsfurey@email.unc.edu | Website: http://fureylab.web.unc.edu/
Research Areas: Computational Genomics, Computational Systems Biology
Research Interests: The Furey Lab is focused on understanding chromatin structure and gene regulation in normal and diseased cells, primarily through the analysis of data from functional high-throughput sequencing experiments.